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Nicotine in e-cigarettes may cause stiffened arteries, which can lead to an increased risk for heart attack and stroke, a small Swedish study suggests. With the dramatic increase in e-cigarette use over the past few years, questions have arisen about their safety. And while many people think the devices are harmless, little is known about long-term effects of these devices, according to lead researcher Magnus Lundback, from the Karolinska Institute in Stockholm. Lundback says, "Increased arterial stiffness has previously been demonstrated following exposure to conventional cigarettes."