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According to Lifehacker, "People who use dietary supplements containing an ingredient called higenamine are playing with fire... meaning people could be dosing themselves with dangerously high levels of the plant-based stimulant." A study was conducted and published in Clinical Toxicology. Dietary Suppelment with higenamine brand themselves as either weight loss or energy supplements. They found tity of higenamine ranged from .001 percent of the listed amount to 200 percent. This makes it unsafe to take the these dietary supplements, because there is no telling how much higenamine is in them